Attenuation of c‐Fos basal expression in the cerebral cortex of aged rat
作者:
Young Lee,
Kyeong Park,
Sang Baik,
Choong Cha,
期刊:
NeuroReport
(OVID Available online 1998)
卷期:
Volume 9,
issue 12
页码: 2733-2736
ISSN:0959-4965
年代: 1998
出版商: OVID
关键词: Aged rats;Basal level of c-Fos;Cerebral cortex;Hippocampal complex
数据来源: OVID
摘要:
CELLULAR immediate early genes (IEG) such as c-foswere originally defined as rapid and transient inducible gene, but their products show a varying degree of basal expression in the brain of normal animals, suggesting that they also play a role in the transcriptional control under physiological conditions. In this study, we used an immunohistochemical method to investigate changes in the number of c-Fos-immunoreactive cells in the cerebral cortex and hippocampal formation of the aged rat. There was a remarkable decrease in the number of c-Fos -immunoreactive cells in the piriform and temporal cortex of aged rats compared with young adult rats. There was a slight decrease in the number of c-Fosimmunoreactive cells in the parietal cortex of aged rat. In the hippocampal complex, there were also decreases in the number of c-Fos-immunoreactive cells in aged rat; the degree of decrease was most prominent in the dentate gyrus. This report provides the first morphological evidence for decreased levels of basal c-Fos expression in some cerebral cortical areas and in the hippocampal complex of aged rats.
点击下载:
PDF
(451KB)
返 回