pH-Induced Difference Spectrophotometric Methods for Drug Analysis. I. Determination of Indomethacin
作者:
SayedM. Hassan,
SoadA. M. Shaaban,
期刊:
Analytical Letters
(Taylor Available online 1982)
卷期:
Volume 15,
issue 21-22
页码: 1693-1699
ISSN:0003-2719
年代: 1982
DOI:10.1080/00032718208065147
出版商: Taylor & Francis Group
数据来源: Taylor
摘要:
On the basis of the spectral changes of indometnacin induced by changing the pH of the solvent medium, a method for its determination has been developed. The latter involves absorbance measurement of both acid and alkaline solutions of the compound at 260 nm: the difference between both values is linearly related to concentration in the range 0.4-1.4 mg/100 ml. The mean percentage recovery of authentic samples equal 100.1±0.42 (p=0.05). The method has been applied to the analysis of pharnaceutical preparations; the results obtained as compared to those of the official method indicate warranty of application in routine analysis.
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