Nmr and Mass Spectroscopic Studies of the Competitive-Angiotensin II Antagonist “Sarmesin”
作者:
JohnM. Matsoukas,
GrahamJ. Moore,
期刊:
Spectroscopy Letters
(Taylor Available online 1988)
卷期:
Volume 21,
issue 5
页码: 477-491
ISSN:0038-7010
年代: 1988
DOI:10.1080/00387018808082323
出版商: Taylor & Francis Group
关键词: Angiotensin conformation;receptor binding;signal recognition and transduction
数据来源: Taylor
摘要:
Fast atom bombardment mass spectrometry (FAB-MS) and high resolution (400 Mz) proton nuclear magnetic resonance (NMR spectroscopy) on the competitive angiotensin II antagonist, |Sar1, Tyr(Me)4(ANGII (Sarmesin) and its he-ptapeptide homolog, [Tyr(Me)3|ANGIII, yield spectra which provide confirmation of structure and molecular weight. The characteristics of the spectra are discussed and compared with the spectra of natural ANG II, ANG III and |Sar1|ANG II. The NMR data are suggestive of interactions in angiotensin between: 1) the phenolic hydroxyl group and the imidazole ring, and 2) the N-terminal amino group and the Tyrring. These interactions may be important for the formation of the proposed charge transfer system in angiotensin II involving the phenoxyl and α-carboxylate groups.
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