The effect of the phenytoin metabolite p-HPPH on proliferation of gingival fibro-blasts in vitro
作者:
ModéerThomas,
DahllöfGöran,
OtteskogPer,
期刊:
Acta Odontologica Scandinavica
(Taylor Available online 1982)
卷期:
Volume 40,
issue 5
页码: 353-357
ISSN:0001-6357
年代: 1982
DOI:10.3109/00016358209024080
出版商: Taylor&Francis
关键词: Cell culture;gingival overgrowth;hyperplasia
数据来源: Taylor
摘要:
The effect of the major phenytoin metabolite 5-(parahydroxyphenyl)-5-phenyl-hydantoin (p-HPPH) was studied on cultures on human fibroblast-like cells grown out from explanted gingival biopsies. The explants were taken from children undergoing phenytoin medication. The results showed that the number of cells per culture decreased whereas the protein and DNA- contents remained relatively unaffected. This effect was most pronounced at the concentrations of 0.20 /μg/ml p-HPPH. The results indicate that the metabolite interfere with cell division without affecting protein or DNA synthesis.
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