Morphological basis for back pain: The demonstration of nerve fibers and neuropeptides in the lumbar facet joint capsule but not in ligamentum flavum
作者:
I. K. Ashton,
B. A. Ashton,
S. J. Gibson,
J. M. Polak,
D. C. Jaffray,
S. M. Eisenstein,
期刊:
Journal of Orthopaedic Research
(WILEY Available online 1992)
卷期:
Volume 10,
issue 1
页码: 72-78
ISSN:0736-0266
年代: 1992
DOI:10.1002/jor.1100100109
出版商: Wiley Subscription Services, Inc., A Wiley Company
关键词: Facet capsule;Ligamentum flavum;Neuropeptides
数据来源: WILEY
摘要:
AbstractThe innervation of lumbar facet capsule and ligamentum flavum was investigated using antisera to a general neuronal marker protein gene product (PGP) 9.5 and to peptide markers of sensory nerves (calcitonin generelated peptide [CGRP] and substance P) and autonomic nerves (vasoactive intestinal polypeptide [VIP]and C‐flanking peptide of neuropeptide Y [CPON]). In the facet capsule (n = 14), PGP 9.5 and CGRP‐immunoreactive nerves occurred in 12 and five specimens, respectively, both around blood vessels and as free fibers in the stroma. Free fibers immunoreactive for substance P or VIP were noted in three and five specimens, whereas in nine specimens there were CPON‐immunoreactive nerves located perivascularly. There was no immunoreactivity in the ligamentum flavum. This study provides further evidence that the facet capsule but not the ligamentum flavum has substantial innervation by sensory and autonomic nerve fibers and has a structural basis for pain perce
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