Almost all infants become attached to their mothers or a mother figure, but many of these attachments are anxious and insecure. Infants in families experiencing multiple risk factors are especially vulnerable for development of attachment problems. Since the quality of the infant-mother attachment is associated with important aspects of the child's development (eg, development of behavior problems), several studies have examined interventions designed to promote secure infant-mother attachments. This article reviews studies of interventions conducted with multirisk families. Implications are drawn from these studies, the attachment literature, and the authors' clinical experience for ways in which professionals in a variety of settings (eg, public health, early intervention, child welfare, day care, pediatrics, specialized therapies) can promote secure infant-mother attachment