Itching in Acne – An Unusual Complication of Therapy
作者:
K.C. Yee,
W.J. Cunliffe,
期刊:
Dermatology
(Karger Available online 1994)
卷期:
Volume 189,
issue 2
页码: 117-119
ISSN:1018-8665
年代: 1994
DOI:10.1159/000246812
出版商: S. Karger AG
关键词: Pruritus;Acne therapy;Histamine;Propionibacterium acnes
数据来源: Karger
摘要:
Pruritus at the site of active acne has not been described before as a complication of acne therapy. We report 8 cases seen over a 3-year period at our department with localized itching mainly at the active acne sites, within 2–6 weeks of starting effective acne therapy. Seven had oral tetracyclines (oxytetracycline, Vibramycin or Minocin) with or without topical antibiotics or benzoyl peroxide. Only 1 patient received oral isotretinoin. The severity of itch was mild to moderate in most cases with the severest reaction in the isotretinoin-treated patient. All cases resolved within 4 weeks, 7 with non-sedative antihistamine therapy (terfenadine), and 1 resolved spontaneously upon cessation of antibiotic therapy. The pathogenesis of this localized itch is presumed to be related to the change in pH of the micro-environment of the acne follicle providing an optimal environment for the production of histamine or histamine-like products by Propionibacterium acnes. This report highlights the self-limiting nature of pruritus during effective anti-acne therapy. Increased awareness of this uncommon complication helps prevent the unnecessary discontinuation of effective acne therap
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