Clinical Experience with Lubeluzole in Patients with Acute Ischaemic Stroke
作者:
Hans-Christoph Diener,
期刊:
Cerebrovascular Diseases
(Karger Available online 1997)
卷期:
Volume 7,
issue 2
页码: 35-38
ISSN:1015-9770
年代: 1997
DOI:10.1159/000108241
出版商: S. Karger AG
关键词: Acute ischaemic stroke;Lubeluzole;Neurological outcome;Functional outcome
数据来源: Karger
摘要:
The neuroprotectant lubeluzole is a benzothiazole compound in late clinical evaluation for the treatment of acute ischaemic stroke. In experimental animals, lubeluzole prevents extracellular glutamate increase following ischaemia, inhibits glutamate-induced nitric oxide-related neurotoxicity and normalises neuronal excitability in the peri-infarct region. Animal models have shown lubeluzole to decrease infarct size following middle cerebral artery occlusion. Promising results in phase I trials of cardiac safety led to a phase II study investigating the effect of lubeluzole, 10 or 20 mg/day, on mortality and neurological and functional recovery in acute ischaemic stroke. Despite an increased mortality rate in the 20 mg/day group, later confirmed as an imbalance of randomisation unrelated to the drug, this trial showed that lubeluzole, 10 mg/day, was well tolerated and reduced mortality. A phase III trial has been recently completed and it is hoped that its results will confirm these findings.
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