Clinical Spectrum of Autoimmune Haemolytic Anaemia in Patients with Chronic Lymphocytic Leukaemia
作者:
MajumdarG.,
BrownS.,
SlaterN. G.,
SinghA. K.,
期刊:
Leukemia&Lymphoma
(Taylor Available online 1993)
卷期:
Volume 9,
issue 1-2
页码: 149-151
ISSN:1042-8194
年代: 1993
DOI:10.3109/10428199309148518
出版商: Taylor&Francis
关键词: Autoimmune haemolytic anaemia;CLL;leukaemia
数据来源: Taylor
摘要:
Autoimmune haemolytic anaemia (AIHA) is a frequent complication of chronic lymphocytic leukaemia (CLL). The course of AIHA in CLL is quite variable and unpredictable. We report 9 patients who showed three distinct clinical patterns. Three patients had a single episode of AIHA which responded rapidly to oral prednisolone. Three others had a relapsing course often associated with a rising lymphocyte count which responded to a combination of prednisolone and cytotoxic drugs. The remaining three patients showed very little response to either form of treatment and continued to have haemolytic anaemia for the remainder of their lives. Development of AIHA did not appear to be associated with any particular stage of the disease and only patients with the third type of AIHA seemed to have a short survival.
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