Gene Therapy for Colorectal CancerTherapeutic Potential
作者:
Ming-Jen Chen,
Guy A. Chung-Faye,
Peter F. Searle,
Lawrence S. Young,
David J. Kerr,
期刊:
BioDrugs
(ADIS Available online 2001)
卷期:
Volume 15,
issue 6
页码: 357-367
ISSN:1173-8804
年代: 2001
出版商: ADIS
关键词: Colorectal cancer, treatment;Colorectal cancer gene therapy, therapeutic use;Gene therapies, therapeutic use;Research and development
数据来源: ADIS
摘要:
Colorectal cancer is a leading cause of cancer mortality in Western countries. Gene therapy has been proposed as a potential novel treatment modality for colorectal cancer, but it is still in an early stage of development. The preclinical data have been promising and numerous clinical trials are underway. This brief review aims to summarise the current status of clinical trials of different gene therapy strategies, including immune stimulation, mutant gene correction, prodrug activation and oncolytic virus therapy, for patients with colorectal cancer. Data from phase I trials have proven the safety of the reagents but have not yet demonstrated significant therapeutic benefit. In order to achieve this and extend the scope of the treatment, continuing efforts should be made to improve the antitumour potency, efficiency of gene delivery and accuracy of gene targeting.
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