Sustained Release Drug Delivery to the LungsAn Option for the Future
作者:
John G. Hardy,
Terence S. Chadwick,
期刊:
Clinical Pharmacokinetics
(ADIS Available online 2000)
卷期:
Volume 39,
issue 1
页码: 1-4
ISSN:0312-5963
年代: 2000
出版商: ADIS
关键词: Controlled release drugs;Lung disorders, treatment
数据来源: ADIS
摘要:
There are potential therapeutic advantages in administering drugs as sustained release formulations to the lungs. This presents the challenges of controlling drug release from particles within the lung environment while overcoming the natural clearance mechanisms. Approaches being adopted involve the administration of particles of small aerodynamic diameter to the alveoli and avoiding phagocytosis by high phospholipid content or large geometric particle size. Studies in animals have demonstrated the utility of such formulations.
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