Stimulation ofin vitroProlactin Release by Vasoactive Intestinal Peptide
作者:
A. Enjalbert,
S. Arancibia,
M. Ruberg,
M. Priam,
M.T. Bluet-Pajot,
W.H. Rotsztejn,
C. Kordon,
期刊:
Neuroendocrinology
(Karger Available online 1980)
卷期:
Volume 31,
issue 3
页码: 200-204
ISSN:0028-3835
年代: 1980
DOI:10.1159/000123074
出版商: S. Karger AG
关键词: PRL;Adenohypophyseal hormones;VIP;PRF;TRH
数据来源: Karger
摘要:
VIP stimulated prolactin secretion from incubated rat hemipituitaries. Under the same conditions, the secretion of GH, LH, FSH was not affected. The stimulation of prolactin was dose-dependent, with an apparent affinity of VIP of 10.9 ± 3.1 nM and a maximal stimulation of 57.7 ± 4.2%. Secretin, a structurally related peptide, was also active at higher concentrations whereas another partial analogue, glucagon, was ineffective. The effect of VIP was not blocked by α-flupentixol, a potent dopaminergic antagonist, at concentrations which antagonized the dopamine inhibition of prolactin secretion. Stimulation by VIP and TRH was additive. Neither Metenkephalin nor naloxone interfered with the response to VIP. It thus seems that specific VIP receptors are present on pituitary prolactin cells. VIP, present in the mediobasal hypothalamus and detected in the hypothalamo-hypophyseal portal blood therefore is a good candidate as a physiological P
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