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USE OF CUMULATIVE DOSE‐RESPONSE CURVES IN POTENCY COMPARISONS OF SYMPATHOMIMETIC AMINES ON PULMONARY RESISTANCE IN ANAESTHETIZED CATS

 

作者: I. W. Rodger,  

 

期刊: Clinical and Experimental Pharmacology and Physiology  (WILEY Available online 1974)
卷期: Volume 1, issue 3  

页码: 211-217

 

ISSN:0305-1870

 

年代: 1974

 

DOI:10.1111/j.1440-1681.1974.tb00543.x

 

出版商: Blackwell Publishing Ltd

 

关键词: airway resistance;heart rate;serotonin;sympathomimetic bronchodilators.

 

数据来源: WILEY

 

摘要:

SUMMARY1. A method for assessing the bronchodilator potency of sympathomimetics in anaesthetized cats is described.2. The bronchodilator actions of laevoisoprenaline, rimiterol and salbutamol, administered by cumulative intravenous injection, were assessed against bronchoconstriction produced by an intravenous infusion of serotonin. Rimiterol and salbutamol, by weight, were each about eight times less potent than laevoisoprenaline.3. The method allows the construction of reproducible dose‐response curves. It is relatively quick, and is especially useful when assessing the potencies of long‐acting sympathomimetic bronchodilat

 

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