Biamperometric titration and differential pulse polarography (DPP) are described for the analysis of nomifensine maleate powder and commercial capsules (MeritalR-50 mg). The biamperometric method involved the titration in cold dil. HCl medium against 0.01 M - NaN02and electrometric detection of end point. The mean percent recoveries obtained were 100.0 ± 0.87 and 99.2 ± 0.95 for the authentic powder and capsules, respectively. The DPP method was performed by measuring the peak current, iP, obtained from the recorded differential polarogram under constant 50mV modulation amplitude. The peak current was measured at the peak potential of − 1.02 V on the dropping mercury electrode (DME) versus Ag/AgCl/KCl (sat.) reference electrode at pH 5.0 (acetate buffer). A linear relationship between peak current and concentration was demonstrated in the range 3 to 30μg ml−1. The mean percent recovery for the capsules was 103.1 ± 1.26.