The Effect of Tamol on Human Mast Cell Chymase and Plasmin
作者:
Oliver Wiedow,
Friedrich Weindler,
Ulrich Mrowietz,
期刊:
Skin Pharmacology and Physiology
(Karger Available online 1997)
卷期:
Volume 10,
issue 2
页码: 90-96
ISSN:1660-5527
年代: 1997
DOI:10.1159/000211474
出版商: S. Karger AG
关键词: Tamol;Plasmin;Chymase
数据来源: Karger
摘要:
Tamol is widely used in the therapy of inflammatory derma-toses. It has pronounced astringent properties and is able to inactivate the neutrophil-derived elastase. Since plasminogen activation and release of mast cell chymase may occur in acute dermatitis, we investigated the inhibitory properties of tamol for these enzymes. Tamol proved to be a potent inhibitor of plasmin and mast cell chymase in concentrations relevant for use in dermatotherapy. The inhibition of mast cell chymase and plasmin by tamol was linear and non-competitive. The inactivation of proteolytic enzymes with the capacity to degrade extracellular-matrix proteins may be one of the major clinical effects of tamol in the treatment of acute inflammatory dermatoses.
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