Fatty acid metabolism in freshwater fish with particular reference to polyunsaturated fatty acids
作者:
R.J. Henderson,
期刊:
Archiv für Tierernaehrung
(Taylor Available online 1996)
卷期:
Volume 49,
issue 1
页码: 5-22
ISSN:0003-942X
年代: 1996
DOI:10.1080/17450399609381859
出版商: Taylor & Francis Group
关键词: Fish;Carp;Lipid metabolism;Polyunsaturated fatty acids
数据来源: Taylor
摘要:
Fatty acids in fish can arise from two sources: synthesisde novofrom non‐lipid carbon sources within the animal, or directly from dietary lipid. Acetyl‐CoA derived mainly from protein can be converted to saturated fatty acids via the combined action of acetyl‐CoA carboxylase and fatty acid synthetase. The actual rate of fatty acid synthesisde novois inversely related to the level of lipid in the diet. Freshwater fish can de‐saturate endogenously‐synthesized fatty acids to monounsaturated fatty acids via a A9 desaturase but lack the necessary enzymes for completede novosynthesis of polyunsaturated fatty acids which must therefore be obtained preformed from the diet. Most freshwater fish species can desaturate and elongate 18:2(n‐6) and 18:3(n‐3) to their C20 and C22 homologues but the pathways involved remain ill‐defined. Cyclooxygenase and lipoxygenase enzymes can convert C20 polyunsaturated fatty acids to a variety of eicosanoid products. The dietary ratio of (n‐3) to (n‐6) polyunsaturated fatty acids influences the pattern of eicosanoids formed. The ß‐oxidation of fatty acids can occur in both mitochondria and peroxisomes but mi‐tochondrial ß‐oxidation is quantitatively more important and can utilise a wide range of fatty acid substrates.
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