Electrophysiologic studies in the Guillain–Barré syndrome: Effects of plasma exchange and antibody rebound
作者:
S. Rudnicki,
F. Vriesendorp,
C. L. Koski,
R. F. Mayer,
期刊:
Muscle&Nerve
(WILEY Available online 1992)
卷期:
Volume 15,
issue 1
页码: 57-62
ISSN:0148-639X
年代: 1992
DOI:10.1002/mus.880150111
出版商: Wiley Subscription Services, Inc., A Wiley Company
关键词: nerve conduction;demyelination;antiperipheral nerve myelin antibodies;antibody rebound;plasmapheresis
数据来源: WILEY
摘要:
AbstractNerve conduction studies (NCS) and antiperipheral nerve myelin antibody (A‐PNM Ab) titers were measured serially in 29 patients with Guillain‐Barré syndrome (GBS), of whom 21 were treated with plasmapheresis. Data were obtained from 3 to 6 days until 1 to 2 years after onset of symptoms. Within 3 to 6 days, mean NCS were abnormal. They improved some by 1 week and became maximally abnormal by 4 to 8 weeks, during which time A‐PNM Ab fell to low levels. In 5 patients plasmapheresed, A‐PNM Ab fell and then increased at 4 to 8 weeks, followed by significant deterioration of NCS (P= 0.01) compared with those without antibody rebound at 18 weeks. These results suggest that, in monophasic GBS, there may be two mechanisms of conduction dysfunction such as early paranodal retraction and later demyelination. In some patients plasmapheresed, A‐PNM Ab may rebound associated with further conduction dysfunction. These patients may benefit from further plas
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