Creutzfeldt‐Jakob Disease in a Pregnant Woman with an Implanted Dura Mater Graft
作者:
Kathryn Lane,
Paul Brown,
David Howell,
Barbara Crain,
Christine Hulette,
Peter Burger,
Stephen DeArmond,
期刊:
Neurosurgery
(OVID Available online 1994)
卷期:
Volume 34,
issue 4
页码: 737-740
ISSN:0148-396X
年代: 1994
出版商: OVID
关键词: Creutzfeldt-Jakob syndrome;Dura mater;Neurosurgery;Pregnancy;Prion diseases;Spongiform encephalopathies;Tissue grafting
数据来源: OVID
摘要:
A 28-YEAR-OLD WOMAN with prior neurosurgery involving the placement of a cadaveric dural graft developed a rapidly progressive neurodegenerative disorder with prominent cerebellar dysfunction that was proven at autopsy to be Creutzfeldt-Jakob disease. She represents the second American to develop Creutzfeldt-Jakob disease in association with a dural graft. The unusual features of the case include the patient's initial clinical presentation with cerebellar ataxia in the absence of dementia, the widespread presence of kuru-type amyloid plaques on a histological examination of the brain, the development of clinical symptoms during pregnancy, and the subsequent delivery of a child who remains healthy at the age of 3 years.
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