Mechanism of Localization of Immune Complexes in NZB/W Mice with Early Nephritis
作者:
GranholmNorman A.,
CavalloTito,
期刊:
Autoimmunity
(Taylor Available online 1990)
卷期:
Volume 8,
issue 1
页码: 17-24
ISSN:0891-6934
年代: 1990
DOI:10.3109/08916939008998428
出版商: Taylor&Francis
关键词: Immune complexes;mechanisms of tissue injury;lupus nephritis;complement;glomerular mesangium.
数据来源: Taylor
摘要:
We investigated the pathogenesis of mesangial proliferative lupus nephritis in NZB/W mice under conditions that allowed us to examine removal of immune complexes from the circulation, uptake by the mononuclear phagocyte system, and localization in kidney tissue. These studies were performed at a time when variables such as the quantity of endogenous immune complexes, complement concentration, and carrier state of blood cells (platelets) were controlled. NZB/W mice and C57BL/6 (control) mice showed comparable kinetics for removal of a subsaturating dose of immune complexes (2.5 mg bovine serum albumin-antibovine serum albumin) from the circulation; additionally, the liver uptake and kidney localization of these immune complexes were comparable between NZB/W and control mice. The localization of immune complexes in the glomerular mesangium of NZB/W mice could not be attributed to enhanced production of endogenous immune complexes, to decreased removal of immune complexes from the circulation, to impaired uptake by the liver, or to complement concentration and carrier state of blood cells. It appears, by exclusion, that mesangial deposits of immunoreactants in early lupus nephritis may result from interaction of antibodies with antigens in mesangia.
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