Inhibition of prostaglandin synthesis by topically applied flurbiprofen in human primary irritant dermatitis
作者:
Vibeke Kassis,
Jørgen Søndergaard,
期刊:
Drug Development Research
(WILEY Available online 1981)
卷期:
Volume 1,
issue 1
页码: 55-58
ISSN:0272-4391
年代: 1981
DOI:10.1002/ddr.430010107
出版商: Wiley Subscription Services, Inc., A Wiley Company
关键词: flurbiprofen;primary irritant dermatitis;prostaglandin E1biosynthesis
数据来源: WILEY
摘要:
AbstractThe inhibitory effect of topically applied flurbiprofen, a newer nonsteroidal antiinflammatory agent, on prostaglandin biosynthesis in human skin biopsies in primary irritant dermatitis was examined. The flurbiprofen‐treated areas synthesized significantly less PGE1(279 pg/mg dry weight) than placebo‐treated inflamed skin (626 pg/mg dry weight). The average inhibition in 11 treated patients was 55% (P<0.01 with Wilcoxon's signed rank test). Furthermore the anti‐inflammatory effect of flurbiprofen was clinically evaluated, and a poor correlation was found between the reduction of prostaglandin synthesis and the clinical effects of flurbip
点击下载:
PDF
(235KB)
返 回