Methylmercury: Effect on serum enzymes and humoral antibody
作者:
L. D. Koller,
JerryH. Exon,
B. Arbogast,
期刊:
Journal of Toxicology and Environmental Health
(Taylor Available online 1977)
卷期:
Volume 2,
issue 5
页码: 1115-1123
ISSN:0098-4108
年代: 1977
DOI:10.1080/15287397709529509
出版商: Taylor & Francis Group
数据来源: Taylor
摘要:
Dosages of 20 and 10 ppm methylmercury were toxic to rabbits while 1 ppm did not produce clinical signs or death. Serum alkaline phosphatase levels were elevated in all rabbits exposed to methylmercury. Methylmercury‐exposed rabbits challenged to A/PR8 influenza virus had hemagglutination inhibition titers as much as four times lower than those of controls. Histopathologic lesions were found in the cerebellum of rabbits that died. The most significant features of this study were that methylmercury chloride suppressed the humoral immune system and resulted in increased serum alkaline phosphatase levels, which may aid in diagnosis when methylmercury poisoning is suspected.
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