SIMULATION AND DESIGN OF BEATING PROFILES IN HEAT CONTROLLED FREEZE-DRYING OF PHARMACEUTICALS IN VIALS BY THE APPLICATION OF A SUBLIMATION CYLINDRICAL MODEL
作者:
J.I. LOMBRANA,
C. DE ELVIRA,
M.C. VILLARAN,
期刊:
Drying Technology
(Taylor Available online 1993)
卷期:
Volume 11,
issue 1
页码: 85-102
ISSN:0737-3937
年代: 1993
DOI:10.1080/07373939308916804
出版商: Taylor & Francis Group
关键词: Freeze-drying;modelling;heating strategies;operating conditions.
数据来源: Taylor
摘要:
A finite element method (FEM) with axial symmetry conditions and isoparametric elements has been applied to describe the freeze drying of a certain pharmaceutical contained in vials in industrial like conditions. Several operating strategies vere proved on the basis of considering three different stages during freeze-drying in relation with the modification of heating and product temperature evolutions. The model offers interesting perspectives to find the most adequate combination of operating conditions in order to reduce drying time.
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