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SIMULATION AND DESIGN OF BEATING PROFILES IN HEAT CONTROLLED FREEZE-DRYING OF PHARMACEUTICALS IN VIALS BY THE APPLICATION OF A SUBLIMATION CYLINDRICAL MODEL

 

作者: J.I. LOMBRANA,   C. DE ELVIRA,   M.C. VILLARAN,  

 

期刊: Drying Technology  (Taylor Available online 1993)
卷期: Volume 11, issue 1  

页码: 85-102

 

ISSN:0737-3937

 

年代: 1993

 

DOI:10.1080/07373939308916804

 

出版商: Taylor & Francis Group

 

关键词: Freeze-drying;modelling;heating strategies;operating conditions.

 

数据来源: Taylor

 

摘要:

A finite element method (FEM) with axial symmetry conditions and isoparametric elements has been applied to describe the freeze drying of a certain pharmaceutical contained in vials in industrial like conditions. Several operating strategies vere proved on the basis of considering three different stages during freeze-drying in relation with the modification of heating and product temperature evolutions. The model offers interesting perspectives to find the most adequate combination of operating conditions in order to reduce drying time.

 

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