Gradual development of folding ability through functional selection
作者:
Seiji Saito,
Masaki Sasai,
Tetsuya Yomo,
期刊:
AIP Conference Proceedings
(AIP Available online 1999)
卷期:
Volume 487,
issue 1
页码: 69-76
ISSN:0094-243X
年代: 1999
DOI:10.1063/1.59897
出版商: AIP
数据来源: AIP
摘要:
Functional selection of sequences according to the local configuration at the active sites is simulated with a spin-glass like model. Starting from a random peptide, the unique native-like conformation emerges with high efficiency with a relatively small number of steps of selection. The functional selection on the active sites is sufficient for sequences to evolve to have the folding ability and relieves the need of exhaustive search in the sequence space. ©1999 American Institute of Physics.
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