Expression of v-fmsand c-fmsin the Hemopoietic Cell Line FDC-P1
作者:
DibbN. J.,
GreenS. M.,
RalphP.,
期刊:
Growth Factors
(Taylor Available online 1990)
卷期:
Volume 2,
issue 4
页码: 301-311
ISSN:0897-7194
年代: 1990
DOI:10.3109/08977199009167025
出版商: Taylor&Francis
关键词: FDC-P1;c-fms;v-fms
数据来源: Taylor
摘要:
A hemopoietic cell line FDC-P1 that requires either IL-3 or GM-CSF to survive and proliferate was infected with retroviruses that expressed either c-fms, which encodes the receptor for M-CSF, or v-fms, which is an oncogenic derivative of c-fms. The expression of c-fmsallowed FDC-P1 to grow in the absence of IL-3 or GM-CSF provided that M-CSF was present. The M-CSF did not, however, induce macrophage differentiation. The expression of v-fmsallowed FDC-P1 to grow in the absence of any added hemopoietic growth factors, including M-CSF, although the addition of M-CSF enhanced v-fmsactivity. V-fmscell lines grew to a higher cell density in suspension and were tumorigenic.
点击下载:
PDF (1647KB)
返 回