Changes in Hypothalamic Neurotransmitter Uptake Following Pinealectomy, Superior Cervical Ganglionectomy or Melatonin Administration to Rats
作者:
D.P. Cardinali,
期刊:
Neuroendocrinology
(Karger Available online 1975)
卷期:
Volume 19,
issue 1
页码: 91-95
ISSN:0028-3835
年代: 1975
DOI:10.1159/000122429
出版商: S. Karger AG
关键词: Hypothalamus;Pineal;Sympathetic cervical ganglia;Melatonin;Serotonin;Transmitter uptake
数据来源: Karger
摘要:
Rats subjected to pinealectomy or to pinealectomy plus bilateral superior cervical ganglionectomy exhibited depressed serotonin uptake by hypothalamic synaptosomes; norepinephrine, dopamine or glutamate uptake was not affected by any of the surgical procedures. Treatment with melatonin resulted in inhibition of hypothalamìc serotonin accumulation but it did not modify the uptake of norepinephrine, dopamine or glutamate. These data suggest a relationship between the pineal gland and the serotoninergic nerve endings of the hypothalamus
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