A Microcomputer Program for Evaluating Sampling Error: an Application to Stereological Methods for Electron Microscopy
作者:
HerbenerGeorge,
GoodflieshRobert,
FassBarry,
期刊:
Biotechnic&Histochemistry
(Taylor Available online 1992)
卷期:
Volume 67,
issue 3
页码: 165-170
ISSN:1052-0295
年代: 1992
DOI:10.3109/10520299209110029
出版商: Taylor&Francis
关键词: software;DOS microcomputers;coefficient of variation;statistics;sampling error;electron microscopy;stereology
数据来源: Taylor
摘要:
In situations where there is a need to minimize sampling error or sample size, the coefficient of variation (CV) may be used to evaluate sampling error as a function of the number of observations or subjects in a sample. For example, CV is useful for estimating the minimum number of electron micrographs (Nmin) required to obtain a representative field sample for stereological analysis. To facilitate the determination of Nmin, we have written a program (COEFficient) for DOS microcomputers which calculates CVs. COEF assists the user in reducing error to that which solely reflects biological variability, thereby minimizing the time and cost of subsequent analyses.
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