Sex Steroids Modulate Prolactin Response to Naloxone in Postmenopausal Women
作者:
G. Benedetto Melis,
Marco Gambacciani,
A. Maria Paoletti,
Valerio Mais,
Angela Cagnacci,
F. Dusca Petacchi,
Piero Fioretti,
期刊:
Neuroendocrinology
(Karger Available online 1985)
卷期:
Volume 41,
issue 2
页码: 138-141
ISSN:0028-3835
年代: 1985
DOI:10.1159/000124167
出版商: S. Karger AG
关键词: Naloxone;Menopause;Prolactin;Sex steroids
数据来源: Karger
摘要:
To evaluate whether ovarian steroids modify the prolactin (PRL) response to opioid receptor blockade, the effects of naloxone infusion (1.6 mg/h for 4 h) on PRL secretion were studied in 5 postmenopausal women. Naloxone infusion was performed in basal conditions and after chronic oral treatment with conjugated estrogens (CE) (1.25 mg/day, for 20 days) or CE plus medroxyprogesterone acetate (MPA) (10 mg/day, for 20 days). Under basal conditions, 17β-estradiol, estrone, gonadotropin, and PRL plasma levels were in the normal range for postmenopausal women, and naloxone failed to affect PRL secretion. Naloxone induced a significant PRL increase after CE treatment alone (p < 0.001) or in combination with MPA (p < 0.001). The increase was significantly higher (p < 0.05) after CE + MPA treatment than after CE treatment alone. These data suggest that steroids modulate the stimulatory effect of naloxone on PRL secretion in postmenopausal women
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