Studies of IgG-Class Anticardiolipin Antibodies in Myasthenia Gravis
作者:
SanmarcoMarielle,
BernardDominique,
期刊:
Autoimmunity
(Taylor Available online 1994)
卷期:
Volume 18,
issue 1
页码: 57-63
ISSN:0891-6934
年代: 1994
DOI:10.3109/08916939409014680
出版商: Taylor&Francis
关键词: Myasthenia gravis;anticardiolipin antibodies;thymoma
数据来源: Taylor
摘要:
IgG-class anticardiolipin antibodies (IgG-ACA) were found in 25% of patients with myasthenia gravis. The prevalence and the level distribution were significantly different from those of a normal donor population (p<0.001). In myastcnic patients, IgG-ACA bound negatively charged, but not zwitteri-onic. phospholipids. They were significantly associated with the thymic abnormalities, thymoma and thymic hyperplasia, but not with various factors such as age, sex, antinuclear antibodies, severity of the disease and clinical thrombosis. The IgG-ACA levels did not correlate with titers of anti-acctylcholine receptor antibodies. Thus in Myasthenia Gravis, asymptomatic IgG-ACA could reflect an immune dysregulation under the influence of thymic alterations.
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