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A conformational study of the adducts of 2′-deoxythymidine and 2,2,6,6-tetramethy...
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A conformational study of the adducts of 2′-deoxythymidine and 2,2,6,6-tetramethyl-1,4-piperidone-N-oxyl by1H and13C nuclear magnetic resonance
作者:
Frank E. Hruska,
Maurice Berger,
Jean Cadet,
Mieczyslaw Remin,
期刊:
Canadian Journal of Chemistry
(NRC Available online 1985)
卷期:
Volume 63,
issue 1
页码: 15-23
ISSN:0008-4042
年代: 1985
DOI:10.1139/v85-003
出版商: NRC Research Press
数据来源: NRC
摘要:
γ-Irradiation of oxygen-free, aqueous solutions of 2′-deoxythymidine in the presence of the organic nitroxide free radical, 2,2,6,6-tetramethyl-1,4-piperidone-N-oxyl (TAN), leads to a complex mixture of products in which the TAN moiety is linked to the C5 or C6 position of a 5,6-saturated thymine ring. Extensive1H and13C nmr data are provided for the eight TAN–dT adducts which are produced in the largest amounts. The results show that the conformational properties of the sugar moiety are dependent on the point of attachment of the TAN group and the configuration of the saturated thymine ring.
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