IFN‐γ induces coordinate expression of MHC class I‐mediated antigen presentation machinery molecules in adult mouse Schwann cells
作者:
Yoshiharu Tsuyuki,
Haruka Fujimaki,
Naoshi Hikawa,
Kiyohide Fujita,
Toshi Nagata,
Mutsuhiko Minami,
期刊:
NeuroReport
(OVID Available online 1998)
卷期:
Volume 9,
issue 9
页码: 2071-2075
ISSN:0959-4965
年代: 1998
出版商: OVID
关键词: b2-Microglobulin;LMP;MHC class I molecule;Schwann cells;TAP
数据来源: OVID
摘要:
THE expression of major histocompatibility complex (MHC) class I molecules on adult mouse Schwann cells (SCs) was examined using immunofluorescence analysis. MHC class I molecules were not expressed on the surface of untreated SCs. Interferon (IFN) γtreatment induced expression of the molecules on the SCs. Expression of genes coding for the molecules involved in MHC class I-mediated antigen presentation was also analysed in SCs by reverse transcription-polymerase chain reaction (RT-PCR). Expression of MHC class I heavy chain genes was faintly detected in untreated SCs. IFN γ treatment augmented the expression. In addition, IFN γ induced expression of the genes fo β2-microglobulin, the peptide transporter TAP-1 and the proteasomal subunit LMP-2, whose expression was not detected in untreated SCs. The expressions of MHC class II molecules and their genes were not detected even after IFN γ treatment. These data suggest that MHC class I-mediated antigen presentation machinery functions in adult mouse SCs and that the SCs themselves work as antigen presenting cells and as targets for cytotoxic T cells in some physiological conditions.
点击下载:
PDF
(275KB)
返 回