Assessment of Occupational Exposure of Pharmaceutical Plant Workers to 5‐Fluorouracil
作者:
Paul,
Sessink Johan,
Timmersmans Rob,
Anzion Rob,
期刊:
Journal of Occupational Medicine
(OVID Available online 1994)
卷期:
Volume 36,
issue 1
页码: 79-83
ISSN:0096-1736
年代: 1994
出版商: OVID
数据来源: OVID
摘要:
The exposure of pharmaceutical plant workers, involved in drug compounding and drug production, to 5-fluorouracil (5FU) was studied. 5FU was found by the analysis of air and wipe samples. During weighing, 5FU was detected in the air (75 μg/m3). 5FU was also present on the filter of the mask of the weigher (120 ng). Before drug compounding 5FU was found on the floor (range, <1 to 8 ng/cm2; median, 2 ng/cm2). After routine cleaning significant higher amounts of 5FU were measured (range, 70 to 630 ng/cm2; median, 150 μg/cm2; P = .02). The amounts of 5FU present on several objects were lower when compared to the amounts on the floor. The gloves used were always contaminated (range, 22 to 720 μg/pair of gloves; median, 141 μg/pair of gloves). The uptake of 5FU was established by the determination of α-fluoro-β-alanine, the main metabolite of 5FU, in the urine of the workers. Fifty micrograms of α-fluoro-β-alanine were found in urine of the weigher.
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