Treatment of Heroin Addicts Using Buprenorphine
作者:
KostenThomas R.,
MorganCharles,
KleberHerbert D.,
期刊:
The American Journal of Drug and Alcohol Abuse
(Taylor Available online 1991)
卷期:
Volume 17,
issue 2
页码: 119-128
ISSN:0095-2990
年代: 1991
DOI:10.3109/00952999108992815
出版商: Taylor&Francis
数据来源: Taylor
摘要:
Thirty-nine opioid-dependent outpatients were treated with the partial agonist buprenorphine at 2 to 6 mg/day for 1 month. Treatment retention was good (72%), and illicit opioid use decreased from 50% overall to 17% for those who remained in treatment. Precipitated withdrawal symptoms were mild and related to dose of buprenorphine. At the end of this month, 28 subjects were abruptly discontinued from buprenorphine and given the antagonist naltrexone. Withdrawal symptoms from buprenorphine were quite mild, and naltrexone was initiated in 20 patients (51 % of total or 71 % of those 28 completing 30 days on buprenorphine), but only 4 patients (10% overall) were successfully maintained on naltrexone for at least 2 weeks.
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