Adaptive Response of Rats with Diet-Induced Adiposity to Energy Restriction
作者:
M. Panemangalore,
C.J. Lee,
K. Wilson,
期刊:
Annals of Nutrition and Metabolism
(Karger Available online 1989)
卷期:
Volume 33,
issue 1
页码: 39-48
ISSN:0250-6807
年代: 1989
DOI:10.1159/000177519
出版商: S. Karger AG
关键词: Adiposity;Energy restriction;Adipose;Lipoprotein lipase;High fat diet;Epididymal fat pads
数据来源: Karger
摘要:
Groups of 4-week old, male Osborne-Mendel rats were given high fat diet (HFD) for 12 weeks; one group was fed control diet (CON) for 28 weeks. HFD rats were transferred to control diet (HFDCON) and diets restricted to 80% (HFDR80) or 60% (HFDR60) of HFDCON intake for another 16 weeks, while one group continued on HFD. Body, liver and epididymal adipose tissue (EPI) weight, and the EPI/body weight ratio of HFDR60 group decreased significantly. EPI lipid content and total lipoprotein lipase activity also declined in response to 40% restriction. Overall, the data indicate that 40% energy restriction can stabilize body weight at a reduced level, and mobilize adipose lipid to meet the energy needs of HFD rats.
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