AbstractSome conventional and experimental anticancer drugs were tested for their effect on Concanavalin A (Con A) -induced Transforming Growth Factor-β(TGF-β) release from BALB/c splenocytes, lipopolysaccharide (LPS)-induced TGF-βrelease from Nude mouse splenocytes and BALB/c peritoneal exudate cells stimulated by LPSin vitro.When 5×106BALB/c and Nude mouse splenocytes/ml stimulated with 1μg/ml Con A, 50ng/ml LPS respectively, and 5×106/ml peritoneal exudate cells stimulated with 50ng/ml LPS were incubated with various non-cytotoxic concentrations of the vinca alkaloid Vincristine, there was an inhibition of the release of TGF-βin culture supernatants of both BALB/c splenocytes and peritoneal exudate cells. But, in Nude mouse Vincristine did not alter the release of TGF-β.The antitumour antibiotic Bleomycin, the immunoactive peptide FK565 and the immunosuppressive agent Cyclosporin A (CsA) were found to have no effect on the release of TGF-βfrom all culture supernatants.