Lymphoproliferative disorders involving Epstein-Barr virus after hemopoietic stem cell transplantation
作者:
Laura Aguilar,
Cliona Rooney,
Helen Heslop,
期刊:
Current Opinion in Oncology
(OVID Available online 1999)
卷期:
Volume 11,
issue 2
页码: 96-96
ISSN:1040-8746
年代: 1999
出版商: OVID
数据来源: OVID
摘要:
Lymphoproliferative disorders involving uncontrolled expansion of donor-derived B cells infected with Epstein-Barr virus (EBV) are a significant problem after hemopoietic stem cell transplantation. Risk factors, which include T cell depletion, major histocompatibility complex mismatch, and intensity of immunosuppression illustrate the importance of T cell immune surveillance. Recent studies have identified viral and host factors that affect the T-cell response to EBV. Monitoring EBV load in the blood by polymerase chain reaction allows early identification of high-risk patients and early institution of therapy. Adoptive immunotherapy approaches using donor T cells have proven effective and EBV-specific cytotoxic T lymphocytes have also been used successfully for prophylaxis. The simplest way of preventing EBV lymphoproliferation, however, may be to deplete B cells from the donor marrow prior to infusion to prevent the transmission of EBV-infected B cells.
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