The Myofibroblast Anchoring Strand — The Fibronectin Connection in Wound Healing and the Possible Loci of Collagen Fibril Assembly
作者:
PAUL BAUR,
DONALD PARKS,
期刊:
The Journal of Trauma: Injury, Infection, and Critical Care
(OVID Available online 1983)
卷期:
Volume 23,
issue 10
页码: 853-862
ISSN:0022-5282
年代: 1983
出版商: OVID
数据来源: OVID
摘要:
Myofibroblast anchoring strands (MAS) are extracellular structures that connect the termini of actin bundles within myofibroblasts to collagen fascicles in the extracellular space of wound healing tissues. The strands appear to be primarily comprised of microfibrils of fibronectin 2–5 nm in diameter. They also embody parallel arrays of intermediary sized filaments (ISF) and an amorphous matrix of collagen. The MAS effectively translate the cellular contractile forces required for cell motility into the collagen filament/fiber deformations required for wound contraction. However, the primary function of the strands appears to be the assembly of ISF into collagen fibrils.
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