Bioavailability to rats of bound [14C] pirimiphos‐methyl in stored wheat
作者:
S.U. Khan,
S. Kacew,
W. Matthews,
期刊:
Journal of Environmental Science and Health, Part B
(Taylor Available online 1992)
卷期:
Volume 27,
issue 4
页码: 355-367
ISSN:0360-1234
年代: 1992
DOI:10.1080/03601239209372786
出版商: Taylor & Francis Group
关键词: Wheat;14C‐Pirimiphos‐methyl;Bound residues Bioavailability
数据来源: Taylor
摘要:
Stored wheat treated with radiolabelled pirimiphos‐methyl (0–2‐diethylamino‐6‐methyl‐pyrimidin‐4‐yl 0,0‐dimethyl phosphorothioate) formed bound (nonextractable)14C residues. Supercritical fluid extraction, gas chromatography and mass spectrometric techniques were used to identify and quantitate the14C bound residues in wheat grains. The amount of bound14C residues present after 28 weeks of storage was about 9.9% of the applied radioactivity. Pirimiphos‐methyl accounted for 80% of the bound residue. Grain‐bound residues were fed to rats for 5 days. After a total period of 8 days a substantially large percentage of the administered bound14C residues (72.9%) was eliminated in urine while feces contained only 17.9%. Bound pirimiphos‐methyl in wheat grain was metabolized in rats by processes involving hydrolysis,N‐dealkylation and O‐demethylation. The results indicate that wheat‐bound residues of pirimiphos‐methyl are highly bioavailable to the rat and may possess a toxicological potential as manifested by a significant reduction in body weight gain.
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