An Improved Capillary Gas Chromatography Method for Triethylamine. Application to Sarafloxacin Hydrochloride and GnRH Residual Solvents Testing
作者:
W. Michael Moore,
Ronald J. Edwards,
Lalit T. Bavda,
期刊:
Analytical Letters
(Taylor Available online 1999)
卷期:
Volume 32,
issue 13
页码: 2603-2612
ISSN:0003-2719
年代: 1999
DOI:10.1080/00032719908542991
出版商: Taylor & Francis Group
关键词: Capillary gas chromatography;Triethylamine;Residual solvents;Validation
数据来源: Taylor
摘要:
A capillary gas chromatography (GC) method for residual solvents in the veterinary antibacterial compound sarafloxacin hydrochloride included triethylamine (TEA). Despite the use of commercially available deactivated columns and inlet liners, the peak shape and reproducibility for the TEA peak were very poor. The use of glass inlet liners and glass wool which were treated with methanolic potassium hydroxide resulted in marked improvement for TEA. This method was also used to determine residual TEA in the polypeptide GnRH.
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