Abnormal Elevation of the Neural Folds in the Loop-Tail Mutant Mouse
作者:
D.B. Wilson,
D.P. Wyatt,
期刊:
Cells Tissues Organs
(Karger Available online 1992)
卷期:
Volume 143,
issue 2
页码: 89-95
ISSN:1422-6405
年代: 1992
DOI:10.1159/000147234
出版商: S. Karger AG
关键词: Spinal cord;Dysraphism;Mouse;Morphometry
数据来源: Karger
摘要:
The processes of elevation and convergence of the spinal neural folds were analyzed in normal (+/+; Lp/+) and abnormal (Lp/Lp) embryos of the loop-tail mutant mouse in order to determine possible mechanisms underlying the dysraphic defect characterized by a failure of the neural fold to close in this mutant. The results indicate that the neural folds are already defective during very early phases of elevation, with greater distances between the apical points of the paired walls of the neural groove, larger ventral angles and higher ratios of luminal/basal linear distances occurring in the abnormal embryos relative to those in normal embryos. The cross-sectional area of the neuroepithelium is also greater in abnormals, suggesting that faulty elongation of the neuraxis may contribute to the dysraphic condition.
点击下载:
PDF
(1089KB)
返 回