Synthesis of GABA‐Valproic Acid Derivatives and Evaluation of Their Anticonvulsant and Antioxidant Activity
作者:
George V. Rekatas,
Ekaterini Tani,
Vassilis J. Demopoulos,
Panos N. Kourounakis,
期刊:
Archiv der Pharmazie
(WILEY Available online 1996)
卷期:
Volume 329,
issue 8‐9
页码: 393-398
ISSN:0365-6233
年代: 1996
DOI:10.1002/ardp.19963290804
出版商: WILEY‐VCH Verlag
关键词: GABA;valproic acid;anticonvulsant activity;lipophilicity;lipid peroxidation
数据来源: WILEY
摘要:
AbstractThe synthesis and the anticonvulsant activity of a number of GABA and valproic acid derivatives are reported. The lipophilicity of these compounds and their inhibitory effect on lipid peroxidation were also investigated, in an effort to correlate the anticonvulsant activity with lipophilicity and inhibitory effect on lipid peroxidation. The synthesized compounds exhibited anticonvulsant effects which were stronger for the more lipophilic derivatives. One of the active anticonvulsants showed appreciable antioxidant properties. Finally, a good correlation was found between the experimentally derived (RM) and calculated (σ and logPSK) lipophilicity for this series of compounds
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