Toxicity of metallic ions in the lung: Effects on alveolar macrophages and alveolar type II cells
作者:
Vincent Castranova,
Linda Bowman,
JoRae Wright,
Howard Colby,
PhilipR. Miles,
期刊:
Journal of Toxicology and Environmental Health
(Taylor Available online 1984)
卷期:
Volume 13,
issue 4-6
页码: 845-856
ISSN:0098-4108
年代: 1984
DOI:10.1080/15287398409530545
出版商: Taylor & Francis Group
数据来源: Taylor
摘要:
Airborne metallic particulates are associated with fossil‐fueled power plants, automobile exhausts, metal mining, and metallurgical smelters. Therefore, the possible toxic effects of metals on the lung are of environmental and occupational concern. In this investigation we determined the effects ofin vitroexposure to metallic ions on the following parameters: oxygen consumption and membrane integrity of alveolar macrophages and type II cells, and chemiluminescence of zymosan‐stimulated alveolar macrophages. Cu2+and Zn2+exhibited marked toxicity to isolated alveolar macrophages and type II cells, while V3+exhibited intermediate toxicity. In contrast, short‐termin vitroexposure to As5+and Se4+had little effect on alveolar macrophages and type II cells. Although the data suggest that exposure to certain metals may be harmful to the lung, the various pulmonary parameters tested in this investigation display differing susceptibility to metal exposure. That is, metals are less toxic to alveolar type II cells than to alveolar macrophages. Our data also indicate that chemiluminescence is the most sensitive assay for monitoring the viability of alveolar macrophages, while oxygen consumption is a sensitive assay for type II cells.
点击下载:
PDF (635KB)
返 回