In Vivo Hypertensive Arterial Wall Uptake of Radiolabeled Liposomes
作者:
Howard Hodis,
John Amartey,
Donald Crawford,
Emily Wickham,
David Blankenhorn,
期刊:
Hypertension
(OVID Available online 1990)
卷期:
Volume 15,
issue 6, Part 1
页码: 600-605
ISSN:0194-911X
年代: 1990
出版商: OVID
关键词: coarctation hypertension;macromolecule carrier systems;liposomes;rabbit studies
数据来源: OVID
摘要:
Using five sham-operated and seven aortic coarctation-induced hypertensive New Zealand White rabbits intravenously injected with neutral small unilamellar vesicles loaded with [“Inlnitrilotriacetic acid, we demonstrated in vivo that the normal aortic arterial wall participates in liposome uptake and that this uptake is increased in the hypertensive aortic wall by approximately threefold (p≤ 0.0001). Among the three regions examined, aortic arch, thoracic aorta, and lower abdominal aorta, the difference in uptake between the normotensive and hypertensive arterial walls was significantly different,p≤ 0.05,p≤ 0.0001, andp≤ 0.05, respectively. The uptake by the different regions of the hypertensive arterial wall is consistent with the pathological changes present in these areas. Furthermore, the extent of liposome uptake by the aortic wall is strongly correlated with the height of the blood pressure (r=0.85, p=0.001, n = 11). We conclude that neutral small unilamellar liposomes can be used to carry agents into the arterial wall in vivo in the study of hypertensive vascular disease and could be especially useful for the delivery of pharmacologically or biologically active agents that would otherwise be inactivated within the circulation or are impermeable to the arterial wall.
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