A severe incapacitating case of obsessive-compulsive neurosis was treated in hospital with an intense multimodal approach including individual, conjoint marital, and group psychotherapy, behavioral therapy, occupational and recreational therapy, milieu therapy, and medications. The separate treatments appeared to have a synergistic effect. The patient's symptoms decreased dramatically, and he resumed his normal occupational and family functions and responsibilities. At 2-year follow-up, the patient remained well.