Visceral Involvement of Dialysis Amyloidosis
作者:
Josep M. Campistol,
Aleix Cases,
Albert Torras,
Manuel Soler,
Josep Muñoz-Gómez,
Jesús Montoliu,
Josep López-Pedret,
Luis Revert,
期刊:
American Journal of Nephrology
(Karger Available online 1987)
卷期:
Volume 7,
issue 5
页码: 390-393
ISSN:0250-8095
年代: 1987
DOI:10.1159/000167505
出版商: S. Karger AG
关键词: Carpal tunnel syndrome;Dialysis amyloidosis;Systemic visceral involvement;β2-Microglobulin
数据来源: Karger
摘要:
Carpal tunnel syndrome, peripheral arthropathy, erosive spondiloarthropathy and lytic bone lesions have all been associated with dialysis amyloidosis. Recent studies indicate that β2-microglobulin is the major constituent protein in this new form of amyloidosis. Dialysis amyloidosis was reported to have a local rather than a systemic involvement, although its full extent is yet to be determined. We investigated 3 patients on maintenance hemodialysis with bilateral caφal tunnel syndrome and amyloid arthropathy and found amyloid depositions in several organs. These findings suggest that, in contrast to what had been thought previously, dialysis amyloidosis could have systemic as well as visceral distribution. The amyloid deposits found were resistant against potassium permanganate treatment and reacted with anti-human β2-microglobulin antibo
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