The half‐life of 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin (TCDD), the contaminant of Agent Orange, has been recently estimated in 36 members of Operation Ranch Hand, the Air Force unit responsible for the aerial spraying of Agent Orange in Vietnam, as 7.1 yr with a 90% confidence interval of 5.8–9.6 yr. We investigated the variability of TCDD half‐life with percent body fat in these 36 Ranch Hand veterans who have two TCDD assay results from serum drawn in 1982 and 1987. Using a repeated measures linear model, we found a marginally significant change in half‐life with percentage of body fat (p ‐ .09) and no statistically significant change in half‐life with relative changes in percentage of body fat from 1982 to 1987 (p ‐ .60).