Multistrain experiments for screening toxic substances
作者:
RobertPaul Felton,
DavidW. Gaylor,
期刊:
Journal of Toxicology and Environmental Health
(Taylor Available online 1989)
卷期:
Volume 26,
issue 4
页码: 399-411
ISSN:0098-4108
年代: 1989
DOI:10.1080/15287398909531264
出版商: Taylor & Francis Group
数据来源: Taylor
摘要:
The advantages of using homogeneous experimental groups (inbred animal strains) and of using multiple groups within an experiment, based on the power of the Mantel‐Haenszel test, were investigated. A simulation experiment was performed to empirically calculate the power of a one‐sided Mantel‐Haenszel test for multistrain experiments. In each case, the power of the multistrain experiment was compared to the (empirical) expected value, over strains, of the power where each strain is tested individually. In the simulation, use of subgroups, each having different response rates, resulted in an increase in power where a chemical exposure caused an average increase of effects in 10% or more of the animals across strains.
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