Parkinson's disease selectively impairs preattentive auditory processingan MEG study
作者:
Eero Pekkonen,
Jyrki Ahveninen,
Juha Virtanen,
Heikki Teräväinen,
期刊:
NeuroReport
(OVID Available online 1998)
卷期:
Volume 9,
issue 13
页码: 2949-2952
ISSN:0959-4965
年代: 1998
出版商: OVID
关键词: Event-related potentials;Magnetoencephalography;N100m;P50m;Parkinson's disease;Preattentive auditory processing
数据来源: OVID
摘要:
AUDITORY stimuli elicit auditory evoked magnetic fields (AEFs) called P50m and N100m, which index preconscious auditory processing in human. We investigated with a whole-head magnetometer whether Parkinson's disease (PD) impairs parallel preattentive auditory processing between the hemispheres. Stimulus blocks consisting of standard (80%) and deviant (20%) tones were monaurally presented in a passive condition to 11 PD patients with unilateral motor symptoms and to 11 age-matched healthy controls. The constant interstimulus intervals (ISIs) were 0.5 s and 2.5 s in separate blocks. The interhemispheric latency differences of the P50m and N100m were significantly lengthened in PD patients in the left-ear condition. This might be caused by the basal ganglia dysfunction in PD together with the simultaneous age-related neural degeneration predominant in the left auditory cortex.
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