DNA Polymorphism of Human HLA-Linked Complement C4 Allotypes, Including C4 Null Alleles, in the Finnish Population
作者:
Jukka Partanen,
Leena Peltonen,
Saija Koskïmies,
Michael C. Carroll,
期刊:
Human Heredity
(Karger Available online 1987)
卷期:
Volume 37,
issue 4
页码: 241-249
ISSN:0001-5652
年代: 1987
DOI:10.1159/000153711
出版商: S. Karger AG
关键词: ComplementRFLP;Deficiency
数据来源: Karger
摘要:
Human HLA-linked complement C4 gene products, C4A and C4B, show extensive genetic polymorphism. In both loci, an allele without a gene product, C4 null, is also observed. We have performed a restriction enzyme analysis of genomic DNA samples from individuals having all common (frequency over 1 %) C4 protein allotypes observed in the Finnish population. Only one allotype-specific RFLP marker was observed. With some enzymes a DNA polymorphism was observed, which was not detectable by C4 protein typing. Analysis of 10 different C4B null haplotypes and 4 C4A null haplotypes suggested that only one haplotype, HLA-B8 C4A0 B1, carried a C4A gene deletion. This was observed in all 4 unrelated individuals homozygous for this haplotype.
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