首页   按字顺浏览 期刊浏览 卷期浏览 Determination of13C Enrichment by Conventional GC-MS and GC-(MS)-C-IRMS
Determination of13C Enrichment by Conventional GC-MS and GC-(MS)-C-IRMS

 

作者: W. Meier-augenstein,   D. Rating,   G.F. Hoffmann,   U. Wendel,   U. Matthiesen,   P. Schadewaldt,  

 

期刊: Isotopes in Environmental and Health Studies  （Taylor Available online 1995）
卷期: Volume 31, issue 3-4  

页码: 261-266

 

ISSN:1025-6016

 

年代: 1995

 

DOI:10.1080/10256019508036268

 

出版商: Taylor & Francis Group

 

关键词: branched-chain amino acids;GC-C-IRMS;GC-MS;MSUD;stable isotope analysis;selected ion monitoring;tracer techniques

 

数据来源: Taylor

 

摘要:

Isotopic enrichment of branched-chain L-amino acids (BCAA) and branched-chain 2-oxo acids (BCOA) in standard preparations and in human plasma samples withdrawn after oral loads with 1-13C labelled BCAA were measured on a conventional GC-MS system and an on-line GC-C-IRMS employing O-TMS quinoxalinol derivatives. It was concluded that the recently introduced GC-C-IRMS, owing to its high sensitivity, is the adequate analytical tool when tracer doses of stable isotope labelled compounds of low enrichment are to be used in biomedicalin vivostudies.

 

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