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Cloning and cerebral expression of the guinea pig histamine H3receptorevidence for two isoforms

 

作者: Joël Tardivel-Lacombe,   Agnés Rouleau,   Anne Héron,   Séverine Morisset,   Catherine Pillot,   Véronique Cochois,   Jean-Charles Schwartz,   Jean-Michel Arrang,  

 

期刊: NeuroReport  （OVID Available online 2000）
卷期: Volume 11, issue 4  

页码: 755-759

 

ISSN:0959-4965

 

年代: 2000

 

出版商: OVID

 

关键词: Alternative splicing;Histamine h1,H2and H3receptors;in situhybridiztion;purkinje cells;Pyranidal cells

 

数据来源: OVID

 

摘要:

We cloned the full length guinea pig H3receptor cDNA using RT-PCR amplification with primers from the human receptor and templates from brain areas. Evidence was obtained for two isoforms, designated H3L and H3S, differing by a 30 amino acid stretch within the third cytosolic loop, presumably generated by alternative splicing.In situhybridization using a selective cRNA probe showed the gene transcripts to be highly expressed in discrete neuronal populations, e.g. pyramidal cells in the cerebral cortex or cerebellar Purkinje cells, in some instances already known to express other histamine receptor subtypes.

 

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